Ex vivo analysis of rotational stiffness of different osteosynthesis techniques in mouse femur fracture
Identifieur interne : 000574 ( Main/Exploration ); précédent : 000573; suivant : 000575Ex vivo analysis of rotational stiffness of different osteosynthesis techniques in mouse femur fracture
Auteurs : Tina Histing [Allemagne, Suisse] ; Joerg H. Holstein [Allemagne, Suisse] ; Patric Garcia [Allemagne, Suisse] ; Romano Matthys [Suisse] ; Alexander Kristen [Allemagne, Suisse] ; Lutz Claes [Allemagne] ; Michael D. Menger [Allemagne, Suisse] ; Tim Pohlemann [Allemagne, Suisse]Source :
- Journal of Orthopaedic Research [ 0736-0266 ] ; 2009-09.
English descriptors
- KwdEn :
- Teeft :
- Attened, Biomechanical, Biomechanical testing, Bone healing, Bone miner, Development institute, Different osteosynthesis techniques, Distally, Femoral, Femoral osteotomies, Femur, Fracture, Fracture healing, Fracture models, Fracture stabilization, Healing, Higher torsional stiffness, Implant, Injection needle, Intercondylar notch, Intramedullary, Intramedullary screw, Locking nail, Locking pins, Locking plate, Molecular mechanisms, Mouse nail, Orthop, Orthopaedic, Orthopaedic research september, Osteosynthesis, Osteotomy, Present study, Proximal thread, Rotational, Rotational instability, Rotational stability, Rotational stiffness, Stabilization, Stiffness, Tibia, Torsional, Torsional stiffness, Xation, Xator, Xator block.
Abstract
The various molecular mechanisms of cell regeneration and tissue healing can best be studied in mouse models with the availability of a wide range of monoclonal antibodies and gene‐targeted animals. The influence of the mechanical stability of individual stabilization techniques on the molecular mechanisms of fracture healing has not been completely elucidated yet. Although during recent years several osteosynthesis techniques have been introduced in mouse fracture models, no comparative study on fracture stabilization is available yet. We therefore analyzed herein in a standardized ex vivo setup the rotational stiffness of seven different osteosynthesis techniques using osteotomized right cadaver femora of CD‐1 mice. Uninjured femora without osteotomy served as controls. Femur stabilization with a locking plate or an external fixator resulted in a rotational stiffness almost similar to the intact femur. The use of a “pin‐clip” device, a “locking nail,” a “mouse nail,” or an “intramedullary screw” produced a lower torsional stiffness, which, however, was still significantly higher than that achieved with the widely applied conventional pin. By the use of the presented data a more specific choice of stabilization technique will be possible according to the various questions concerning molecular aspects in fracture healing. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 1152–1156, 2009
Url:
DOI: 10.1002/jor.20849
Affiliations:
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Orthop. Res.</title><idno type="ISSN">0736-0266</idno><idno type="eISSN">1554-527X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-09">2009-09</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1152">1152</biblScope><biblScope unit="page" to="1156">1156</biblScope></imprint><idno type="ISSN">0736-0266</idno></series><idno type="istex">A574920B141408D669873079CA66F8F81E55ED0E</idno><idno type="DOI">10.1002/jor.20849</idno><idno type="ArticleID">JOR20849</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0736-0266</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>bone healing</term><term>femur fracture</term><term>mice</term><term>osteosynthesis</term><term>torsional stiffness</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Attened</term><term>Biomechanical</term><term>Biomechanical testing</term><term>Bone healing</term><term>Bone miner</term><term>Development institute</term><term>Different osteosynthesis techniques</term><term>Distally</term><term>Femoral</term><term>Femoral osteotomies</term><term>Femur</term><term>Fracture</term><term>Fracture healing</term><term>Fracture models</term><term>Fracture stabilization</term><term>Healing</term><term>Higher torsional stiffness</term><term>Implant</term><term>Injection needle</term><term>Intercondylar notch</term><term>Intramedullary</term><term>Intramedullary screw</term><term>Locking nail</term><term>Locking pins</term><term>Locking plate</term><term>Molecular mechanisms</term><term>Mouse nail</term><term>Orthop</term><term>Orthopaedic</term><term>Orthopaedic research september</term><term>Osteosynthesis</term><term>Osteotomy</term><term>Present study</term><term>Proximal thread</term><term>Rotational</term><term>Rotational instability</term><term>Rotational stability</term><term>Rotational stiffness</term><term>Stabilization</term><term>Stiffness</term><term>Tibia</term><term>Torsional</term><term>Torsional stiffness</term><term>Xation</term><term>Xator</term><term>Xator block</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The various molecular mechanisms of cell regeneration and tissue healing can best be studied in mouse models with the availability of a wide range of monoclonal antibodies and gene‐targeted animals. The influence of the mechanical stability of individual stabilization techniques on the molecular mechanisms of fracture healing has not been completely elucidated yet. Although during recent years several osteosynthesis techniques have been introduced in mouse fracture models, no comparative study on fracture stabilization is available yet. We therefore analyzed herein in a standardized ex vivo setup the rotational stiffness of seven different osteosynthesis techniques using osteotomized right cadaver femora of CD‐1 mice. Uninjured femora without osteotomy served as controls. Femur stabilization with a locking plate or an external fixator resulted in a rotational stiffness almost similar to the intact femur. The use of a “pin‐clip” device, a “locking nail,” a “mouse nail,” or an “intramedullary screw” produced a lower torsional stiffness, which, however, was still significantly higher than that achieved with the widely applied conventional pin. By the use of the presented data a more specific choice of stabilization technique will be possible according to the various questions concerning molecular aspects in fracture healing. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 1152–1156, 2009</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Histing, Tina" sort="Histing, Tina" uniqKey="Histing T" first="Tina" last="Histing">Tina Histing</name></noRegion><name sortKey="Claes, Lutz" sort="Claes, Lutz" uniqKey="Claes L" first="Lutz" last="Claes">Lutz Claes</name><name sortKey="Garcia, Patric" sort="Garcia, Patric" uniqKey="Garcia P" first="Patric" last="Garcia">Patric Garcia</name><name sortKey="Garcia, Patric" sort="Garcia, Patric" uniqKey="Garcia P" first="Patric" last="Garcia">Patric Garcia</name><name sortKey="Histing, Tina" sort="Histing, Tina" uniqKey="Histing T" first="Tina" last="Histing">Tina Histing</name><name sortKey="Holstein, Joerg H" sort="Holstein, Joerg H" uniqKey="Holstein J" first="Joerg H." last="Holstein">Joerg H. Holstein</name><name sortKey="Holstein, Joerg H" sort="Holstein, Joerg H" uniqKey="Holstein J" first="Joerg H." last="Holstein">Joerg H. Holstein</name><name sortKey="Kristen, Alexander" sort="Kristen, Alexander" uniqKey="Kristen A" first="Alexander" last="Kristen">Alexander Kristen</name><name sortKey="Menger, Michael D" sort="Menger, Michael D" uniqKey="Menger M" first="Michael D." last="Menger">Michael D. Menger</name><name sortKey="Pohlemann, Tim" sort="Pohlemann, Tim" uniqKey="Pohlemann T" first="Tim" last="Pohlemann">Tim Pohlemann</name></country><country name="Suisse"><noRegion><name sortKey="Histing, Tina" sort="Histing, Tina" uniqKey="Histing T" first="Tina" last="Histing">Tina Histing</name></noRegion><name sortKey="Garcia, Patric" sort="Garcia, Patric" uniqKey="Garcia P" first="Patric" last="Garcia">Patric Garcia</name><name sortKey="Holstein, Joerg H" sort="Holstein, Joerg H" uniqKey="Holstein J" first="Joerg H." last="Holstein">Joerg H. Holstein</name><name sortKey="Kristen, Alexander" sort="Kristen, Alexander" uniqKey="Kristen A" first="Alexander" last="Kristen">Alexander Kristen</name><name sortKey="Matthys, Romano" sort="Matthys, Romano" uniqKey="Matthys R" first="Romano" last="Matthys">Romano Matthys</name><name sortKey="Menger, Michael D" sort="Menger, Michael D" uniqKey="Menger M" first="Michael D." last="Menger">Michael D. Menger</name><name sortKey="Pohlemann, Tim" sort="Pohlemann, Tim" uniqKey="Pohlemann T" first="Tim" last="Pohlemann">Tim Pohlemann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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